Barcelona will secure top spot in their group with another positive result on Wednesday in what is arguably the biggest game of Champions League matchday five.
Lionel Messi is close to a personal milestone but Juventus will be desperate to avenge their 3-0 loss at Camp Nou and secure passage to the last 16 themselves.
Manchester United are also on the brink of the knockout phase and will look to fit-again Paul Pogba to improve on a pretty miserable record in the competition, while Paris Saint-Germain represent a daunting prospect for Celtic and Brendan Rodgers.
Chelsea will look to follow them into the next round and will hope Eden Hazard continues his electric form against Qarabag, while Atletico Madrid and Roma face off in a potentially pivotal showdown in the Spanish capital.
Below, we examine the key Opta numbers behind Wednesday's fixtures.
CSKA Moscow v Benfica
57 – CSKA are on six points after their first four matches; 57 per cent of sides to hold this record at this stage in the Champions League since 2003-04 (current format) have progressed to the next phase.
5 – Benfica have lost five Champions League matches in succession and have only managed to score once in this campaign; only Anderlecht have recorded fewer goals (0).
Basel v Manchester United
13 – No English side has ever managed to keep a clean sheet on the road against Basel in European competition (13 such fixtures); the Swiss club have claimed 1-0 victories in two of their last three home games versus English opposition.
33 – Paul Pogba has only scored two goals in 33 Champions League games.
Paris Saint-Germain v Celtic
17 – Paris Saint-Germain have scored more goals than anybody else this season in the Champions League (17) and are the only remaining side in the competition to record clean sheets in every game this term.
2 – Brendan Rodgers has won only two of his 16 group games as manager in the Champions League. Those victories came against Ludogorets (2-1) in September 2014, when he was in charge of Liverpool, and Celtic's 0-3 versus Anderlecht.
Anderlecht v Bayern Munich
18 – Anderlecht have only managed to register one clean sheet in their last 18 Champions League outings, while their German opponents have failed to record any in their last 10 on the road in this competition.
29 – Bayern Munich attempted 29 shots and hit the target 11 times in their 3-0 victory at home to Anderlecht on matchday one; Anderlecht recorded just one shot on target in response.
Qarabag v Chelsea
90 – Qarabag are yet to win a game this season in the Champions League; only on three previous occasions has a club progressed to the last 16 since 2003-04 (current format) in 90 instances after having failed to claim a win in the opening four matchdays.
17 – Eden Hazard has created more goalscoring chances than any other player in the 2017-18 Champions League campaign (17).
Atletico Madrid v Roma
4 – Roma have tasted defeat in four of their last five visits to Spanish clubs in the Champions League (W1), letting in 15 goals across those matches (an average of three per game).
9 – Nine of the last 14 Champions League goals scored by Atletico Madrid have seen the direct involvement of Antoine Griezmann (scored seven, assisted two).
Sporting CP v Olympiacos
1 – Only one team (Qarabag, seven) has recorded fewer shots on target this term in the Champions League than Olympiacos (nine); Sporting could only manage two on matchday four versus Juventus, but they came away with a 1-1 draw.
19 – Olympiacos' Silvio Proto has made 19 saves in three Champions League appearances this season, an average of over six per game, which is the highest rate of any keeper to register more than one outing in this campaign.
Juventus v Barcelona
29 – Juventus have only lost once in their last 29 home games against Spanish opposition in European competition (W19 D9), conceding only one goal across their last five such fixtures.
100 – Lionel Messi is just a hat-trick away from becoming only the second player to record 100 goals in the Champions League (after Cristiano Ronaldo). He scored a brace on matchday one against Juventus.
|Atletico Madrid 2 Athletic Bilbao 0: Gameiro and Costa settle cagey clash|
|Napoli set club record with another Serie A win|
|Napoli 1 SPAL 0: Allan sends hosts top of Serie A again|
|Allegri allays Higuain injury fears|
|Allegri convinced Juve can get past Spurs|
|Everton fear ´long-term´ injury for Mangala|
|If it isn´t Madrid, it´s Paris - Hazard tires of speculation|
|Torino 0 Juventus 1: Champions win derby but lose Higuain|
|Neymar exit made Barcelona stronger - Ter Stegen|
|Injured Higuain forced off against Torino|
|Jesus confident of returning strong after knee injury|
|We had to change hotels – Ovrebo recalls fury after 2009 Chelsea-Barcelona semi-final|
|Spalletti: Inter board will decide my future|
|Fabregas still wary of timeless Iniesta|
|Liverpool´s 30-goal hero Salah: There´s more to come|
|Valverde: Coutinho dropped for the good of Barcelona|
|Ronaldo better than Neymar? No says Xavi|
|Real Madrid hurt you with nothing – Xavi says PSG loss an injustice|
|Conte: Chelsea need perfect game to stop Messi and Barcelona|
|Inter in a fragile moment, says Spalletti|
|Booed Emery praises PSG´s mental strength|
|Cavani hails ´good reaction´ as PSG bounce back in style|
|Mourinho wants referees to have final say on VAR|
|Genoa 2 Inter 0: Pandev piles misery on old employers|
|Manchester United to host Brighton in FA Cup quarter-finals|
|Mata ´still up for VAR´ despite disallowed goal at Huddersfield|
|Valverde: Barcelona had to suffer at Eibar|
|Championship Review: Fulham end Villa run, Cardiff pounce|
|Huddersfield Town 0 Manchester United 2: Lukaku sends visitors through after VAR controversy|
|Bayern Munich boss Heynckes hails game-changing Muller|
|Locadia benefiting from ´competitive´ Brighton - Hughton|
|Baby on board? Alba dedicates Barca goal to girlfriend|
|West Brom future ´not a decision for me´, says Pardew|
|Paris Saint-Germain 5 Strasbourg 2: Cavani at the double in bounce-back win|
|Bar-celona! Messi posts unwanted record|
|Barca go 31 LaLiga games unbeaten to tie club record|
|Mourinho: I don´t know and I don´t care when Pogba returns|
|Brighton and Hove Albion 3 Coventry City 1: Locadia, Ulloa lead Seagulls to quarter-finals|
|EIbar 0 Barcelona 2: Suarez and Alba seal points as Orellana sees red|
|West Brom 1 Southampton 2: Rondon stunner in vain as Baggies drop out|
|Wolfsburg 1 Bayern Munich 2: Lewandowski spot-on after Robben´s penalty miss|
|I hope Cutrone finds a beautiful girlfriend so he can rest and make love - Gattuso|
|Allegri denies Champions League ´obsession´ ahead of Turin derby|
|Barry, Evans start for West Brom after training camp incident|
|Sheffield Wednesday 0 Swansea City 0: Carvalhal settles for replay on Hillsborough return|
|Management ´tiring´ but Zidane not ready to leave Madrid just yet|
|Thiago back for Bayern as Heynckes rests stars for Besiktas|
|Simeone urges Atletico fans to get behind Griezmann|
|Robben amazed by Guardiola´s impact at Manchester City|
|Pogba out of Man Utd´s Huddersfield trip with illness|
|A-League Review: Perth ´Panenka´ punished, 10-man Adelaide rescue late draw|
|Robben targets two more years at the ´highest level´|
|Rashford and Herrera ´have a chance´ of making Sevilla trip|
|Emery defends PSG star Neymar after Madrid display|
|Mahrez saga now over, says Leicester boss Puel|
|Alonso to return for Barca clash but Bakayoko set to miss first leg – Conte|
|Mourinho: Manchester United will sign a midfielder|
|Conte given selection headache ahead of Barcelona clash|
|Giroud ´relieved´ to get first Chelsea goal|
|Chelsea 4 Hull City 0: Giroud scores and Willian stars as Blues reach last eight|
|Leicester City 1 Sheffield United 0: Vardy header secures quarter-final spot|
|I cry often and I cry alone - Buffon benefits from his emotional side|
|Mason retirement ´heart-breaking´, says Cahill|
|Evans, Barry and Livermore among West Brom players to apologise for ´curfew breach´|
|Mahrez starts for Leicester City in FA Cup|
|Vermaelen backs Chelsea-linked Luis Enrique for Premier League job|
|Low succeeding Heynckes at Bayern in 2019 is Matthaus´ ´dream´|
|Bellerin criticises ArsenalFanTV: How can that be a fan?|
|Juventus striker Higuain takes aim at critics again|
|Mourinho is more of a winner – Montella admires Manchester United boss|
|Pardew ´let down´ as West Brom investigate Barcelona incident|
|Carrick mentoring potential successor McTominay|
|Knee infection rules Mooy out of Huddersfield v Man United|
|UEFA inspectors receive death threats over Skenderbeu match-fixing investigation|
|Aguero claims player of the month after goal-laden February|
|Valverde deflects Argentina request to rest Messi|
|Bennell crimes ´a terrible, terrible situation´, says Guardiola|
|Kane a doubt for Rochdale after suffering knock against Juventus|
|Guardiola wary of Wigan as Jesus returns to Man City training|
|Mourinho refuses to blame ´big injury´ for Pogba´s loss of form|
|Perisic joins Icardi on Inter sidelines against Genoa|
|Potential rise in Batshuayi interest does not faze Stoger|
|Mourinho hits out at ´lies´ over reported Pogba row|
|Emery convinced PSG can qualify against Real Madrid|
|Heynckes caught napping by Bayern´s Schalke win|
|Real Madrid confirm Kroos knee injury|
|I never said that the road would be easy - Neymar responds to Madrid defeat|
|Former Mourinho assistant Morais takes over at Barnsley|
|Ronaldo scores with his knee or his belly - Heynckes notes Madrid fortune vs PSG|
|Howe ends Guardiola´s manager of the month streak|
|Western Sydney Wanderers 2 Newcastle Jets 2: Nabbout stunner earns point|
|Scotland turn back to McLeish|
|No return date for Neuer as Heynckes backs keeper for World Cup|
|Sometimes frustrating Depay ´needs love´ from Lyon|
|Iniesta: Stamford Bridge return will be special|
|No planning for Messi, you just react - Deco|
|Liverpool can win Champions League, says Lovren|
|We lacked hunger and enthusiasm – Sarri slams Napoli|
|Zidane has won enough – Kroos backs Real Madrid coach|
|Casagrande slams ´monster´ Neymar, PSG star´s father hits back|
|Mane ´never doubted´ he would get back to best|
|Wenger not expecting wholesale changes for Ostersunds second leg|
|Gattuso ´angry´ with comfortable Milan win|
|Simeone satisfied with Atletico Madrid comeback in Copenhagen|
|First-leg win gives Celtic ´a wonderful opportunity´, says Rodgers|