1. 15:00

   F

   Arsenal

   Crystal Palace

   4 2

   1 0

   Gabriel Martinelli 28'	1 - 0
   B. Saka 43'	2 - 0
   G. Xhaka 55'	3 - 0
   	3 - 1	63' J. Schlupp
   B. Saka 74'	4 - 1

1. 15:30

   F

   Union Berlin

   Francfort

   2 0

   0 0

   R. Khedira 53'	1 - 0
   K. Behrens 75'	2 - 0

2. 17:30

   F

   Leverkusen

   Bayern Munich

   2 0

   1 1

   	0 - 1	22' J. Kimmich
   E. Palacios 55'	1 - 1
   E. Palacios 73'	2 - 1

3. 19:30

   F

   Mayence

   Fribourg

   1 0

   1 0

   	0 - 1	55' R. Dōan
   K. Onisiwo 90+6'	1 - 1

1. 13:30

   F

   Swansea

   Bristol City

   2 1

   0 0

   L. Cullen 34'	1 - 0
   O. Ntcham 77'	2 - 0

1. 14:00

   F

   Betis

   Majorque

   1 0

   0 0

   Borja Iglesias 48'

   1 - 0

2. 16:15

   F

   Osasuna

   Villarreal

   0 0

   3 1

   	0 - 1	14' S. Chukwueze
   	0 - 2	85' José Luis Morales
   	0 - 3	90+3' José Luis Morales

3. 16:15

   F

   Real Sociedad

   Elche

   2 0

   0 0

   T. Kubo 48'	1 - 0
   Barrenetxea 90'	2 - 0

4. 18:30

   F

   Getafe

   Séville

   2 0

   0 0

   M. El Haddadi 50'	1 - 0
   E. Ünal 90+5'	2 - 0

5. 21:00

   F

   Barcelone

   Real Madrid

   2 1

   1 1

   	0 - 1	9' R. Araujo
   Sergi Roberto 45'	1 - 1
   F. Kessié 90+2'	2 - 1

1. 12:30

   F

   Sampdoria

   Hellas

   3 2

   1 0

   M. Gabbiadini 24'	1 - 0
   M. Gabbiadini 35'	2 - 0
   	2 - 1	88' M. Faraoni
   A. Zanoli 90+8'	3 - 1

2. 15:00

   F

   Fiorentina

   Lecce

   1 1

   0 0

   A. Gallo 27'

   1 - 0

3. 15:00

   F

   Torino

   Naples

   0 0

   4 2

   	0 - 1	9' V. Osimhen
   	0 - 2	35' K. Kvaratskhelia
   	0 - 3	51' V. Osimhen
   	0 - 4	68' T. Ndombélé

4. 18:00

   F

   Lazio

   1. 

   Rome

   1. 
   2. 

   1 0

   0 0

   		32' Ibañez
   M. Zaccagni 65'	1 - 0
   A. Marušić 90+7'
   		90+7' B. Cristante

5. 20:45

   F

   Inter Milan

   1. 

   Juventus

   1. 

   0 0

   1 1

   	0 - 1	23' F. Kostić
   D. D'Ambrosio 90+8'
   		90+8' L. Paredes

1. 13:00

   F

   Éthiopie

   Rwanda

   1

   0

1. 13:00

   F

   Sheff Utd

   Blackburn

   3 1

   2 1

   	0 - 1	21' B. Brereton
   S. Gallagher 28'	1 - 1
   	1 - 2	60' S. Szmodics
   O. McBurnie 81'	2 - 2
   T. Doyle 90+1'	3 - 2

2. 15:15

   F

   Brighton

   Grimsby

   5 1

   0 0

   D. Undav 6'	1 - 0
   E. Ferguson 51'	2 - 0
   E. Ferguson 70'	3 - 0
   S. March 82'	4 - 0
   K. Mitoma 90'	5 - 0

3. 17:30

   F

   Man United

   Fulham

   1. 
   2. 

   3 0

   1 0

   	0 - 1	50' A. Mitrović
   		72' Willian
   		72' A. Mitrović
   Bruno Fernandes 75'	1 - 1
   M. Sabitzer 77'	2 - 1
   Bruno Fernandes 90+6'	3 - 1

1. 13:30

   F

   Antwerp

   Sporting Charleroi

   1. 

   0 0

   1 1

   	0 - 1	15' Y. Badji
   		60' D. Marcq

2. 16:00

   F

   Louvain

   Anderlecht

   0 0

   2 1

   	0 - 1	33' I. Slimani
   	0 - 2	90' K. Arnstad

3. 18:30

   F

   R. Union SG

   Malines

   2 1

   1 1

   	0 - 1	4' J. Ngoy
   L. Lapoussin 10'	1 - 1
   T. Teuma 56'	2 - 1

4. 19:15

   F

   La Gantoise

   Eupen

   3 1

   0 0

   H. Cuypers 45+1'	1 - 0
   J. Davidson 77'	2 - 0
   J. Okumu 85'	3 - 0

1. 12:15

   F

   Groningen

   Heerenveen

   0 0

   2 2

   	0 - 1	27' S. van Hooijdonk
   	0 - 2	40' S. van Hooijdonk

2. 14:30

   F

   Ajax

   Feyenoord

   2 2

   3 1

   	0 - 1	5' S. Giménez
   E. Álvarez 17'	1 - 1
   D. Tadić 37'	2 - 1
   	2 - 2	52' S. Szymański
   	2 - 3	86' L. Geertruida

3. 14:30

   F

   Excelsior

   Cambuur

   4 4

   1 0

   K. Goudmijn 6'	1 - 0
   L. Bergsma 10'	2 - 0
   S. Horemans 20'	3 - 0
   L. Lamprou 33'	4 - 0
   	4 - 1	50' A. Bangura

4. 16:45

   F

   Vitesse

   PSV

   1 0

   1 1

   	0 - 1	8' X. Simons
   I. Sangaré 61'	1 - 1

5. 20:00

   F

   Twente

   AZ

   2 2

   1 0

   M. Ugalde 8'	1 - 0
   M. Ugalde 11'	2 - 0
   	2 - 1	66' J. Karlsson

1. 16:30

   F

   Casa Pia

   Maritimo

   1. 

   2 1

   0 0

   Felippe Cardoso 41'	1 - 0
   Felippe Cardoso 50'	2 - 0
   		86' Renê

2. 19:00

   F

   Sporting Braga

   Porto

   0 0

   0 0
3. 21:30

   F

   Boavista

   Famalicão

   1 0

   2 0

   	0 - 1	57' Iván Jaime
   	0 - 2	60' A. Dobre
   R. Boženík 72'	1 - 2

1. 12:00

   F

   Khimki

   1. 

   Rostov

   0 0

   1 1

   	0 - 1	18' M. Osipenko
   Janio Bikel 29'

2. 14:30

   F

   Krylya

   Akhmat

   0 0

   1 0

   0 - 1

   46' A. Timofeev

3. 14:30

   F

   Nizhny Novg.

   Torpedo

   0

   3

   K. Gotsuk 34'	1 - 0
   	1 - 1	58' Y. Reyna

4. 17:30

   F

   CSKA

   Zénith

   1 0

   0 0

   F. Chalov 72'

   1 - 0

1. 14:00

   F

   Sivasspor

   MKE Ankaragücü

   2 1

   0 0

   I. Cofie 23'	1 - 0
   Samuel Sáiz 77'	2 - 0

2. 14:00

   F

   Fatih

   Basaksehir

   2 1

   2 1

   	0 - 1	42' D. Aleksić
   F. Borini 45+4'	1 - 1
   	1 - 2	90+1' S. Gürler
   M. Diagne 90+2'	2 - 2

3. 17:00

   F

   Gaziantep FK

   Trabzon

   0

   3
4. 17:00

   F

   Alanya

   Fenerbahce

   1 1

   3 0

   E. Koulouris 4'	1 - 0
   	1 - 1	65' E. Valencia
   	1 - 2	85' E. Valencia
   	1 - 3	90+2' E. Mor

5. 17:00

   F

   Kayserispor

   Hatay

   3

   0

Group A

1. 14:00

   F

   Saint Éloi Lupopo

   USM Alger

   1 0

   1 0

   H. Mwaku 72'	1 - 0
   	1 - 1	90' A. Kateregga

2. 18:00

   F

   Al-Akhdar

   Gallants

   4 1

   1 0

   Anas Alraheem 31'	1 - 0
   Ary Papel 50'	2 - 0
   	2 - 1	61' M. Mvelase
   Ary Papel 66'	3 - 1
   Mohamed Makari 73'	4 - 1

Group B

1. 17:00

   F

   Rivers Utd

   Diables Noirs

   2 0

   2 1

   	0 - 1	28' E. Ampiah
   N. Nwagua 73'	1 - 1
   N. Nwagua 77'	2 - 1
   	2 - 2	81' D. Bassinga

2. 20:00

   F

   Motema Pembe

   ASEC

   1 0

   2 1

   	0 - 1	27' A. Kramo
   K. Yallet 52'	1 - 1
   	1 - 2	90' A. Kramo

Group C

1. 17:00

   F

   Future

   ASKO de Kara

   3 1

   0 0

   Ali Elfeel 41'	1 - 0
   Mohanad Lasheen 72'	2 - 0
   Ahmed Atef 87'	3 - 0

2. 20:00

   F

   FAR Rabat

   Pyramids

   1 0

   0 0

   A. Hammoudan 61'

   1 - 0

Group D

1. 17:00

   F

   Réal Bamako

   TP Mazembe

   2 1

   1 0

   O. Kamissoko 45+2'	1 - 0
   O. Kamissoko 61'	2 - 0
   	2 - 1	67' F. Traoré

2. 17:00

   F

   Young Africans

   Monastir

   2 1

   0 0

   K. Musonda 33'	1 - 0
   F. Mayele 59'	2 - 0