Spain secured their place in the 2018 World Cup after they eased to a 3-0 Group G win over Albania as Gerard Pique received a mixed reception.
Julen Lopetegui's men approached Friday's contest in Alicante knowing they would qualify for the finals in Russia by bettering Italy's result against Macedonia.
But, given the disparity in quality between the two teams, Spain's vastly superior goal difference and head-to-head advantage over Italy, the spotlight was always likely to be on Barcelona defender Pique.
Pique, who has been vocal in his support of a referendum on Catalonia's attempts to secede from Spain, was whistled at an open training session on Monday.
And the centre-back received the same treatment from his first touch at Estadio Jose Rico Perez, but was later brought off predominantly to applause in the second half.
Rodrigo opened the scoring in the 16th minute with a fine close-range effort before Isco's fourth goal in three Spain matches and Thiago Alcantara's header made the game safe in the space of 10 minutes.
Italy's 1-1 draw with Macedonia means Spain go into the final round of fixtures on Monday guaranteed a place in the tournament proper, holding a five-point lead at the top, while Albania's slim hopes of earning a play-off spot are over.
Rodrigo spurned an early chance to put Spain ahead as he stabbed wide from Jordi Alba's left-wing cross before Azdren Llullaku forced David De Gea into a routine save at the other end.
A glorious opportunity went begging with Rodrigo again at fault as he failed to convert Isco's right-wing cross, heading wide from close range, but the Valencia forward soon atoned for his profligacy.
He controlled Isco's clever pass with his head before smashing a superb stretching half-volley beyond Etrit Berisha to open the scoring.
Sergio Ramos then saw a header turned over before his Real Madrid team-mate Isco doubled the lead.
Koke played Isco in at the near post and he made no mistake in lashing into the top-left corner.
That seemingly put the game beyond doubt but Albania almost responded as Llullaku clattered a header against the crossbar.
But that proved only a brief interlude to Spain's dominant showing and Thiago soon made it 3-0 by nodding in after Alvaro Odriozola surged down the right culminated in a pinpoint cross.
Rodrigo was denied a second by Berisha and Alba fired wide as Spain threatened to turn the contest into a rout, though Pique was fortunate not to see a defensive error on the stroke of half-time not result in a goal for Albania.
Alba stood up a cross for Koke, who saw his header parried by Berisha as Spain kept the pressure on after the restart, with Rodrigo again thwarted by the Albania goalkeeper after some haphazard defending.
Armando Sadiku headed against the left-hand post, but moments of danger were fleeting for Spain and, with their qualification confirmed, they can reflect on an extremely impressive campaign and look ahead to Russia perhaps with questions about Pique's international future put to one side after the early whistles were drowned out.
|Sarri praises ´extraordinary´ Hamsik as Napoli go top of Serie A|
|Mutual trust at Man City is ´a dream´, says Guardiola|
|Stoger´s small changes getting Dortmund back on track|
|Atletico Madrid 1 Alaves 0: Substitute Torres breaks LaLiga duck to net winner|
|City defeat a ´good experience´ for Tottenham - Pochettino|
|Zidane dreaming of sextuple after Club World Cup success|
|Running man De Bruyne makes it easier to manage City - Guardiola|
|Ronaldo and Zidane hoping for Ballon d´Or winner to retire at Madrid|
|Championship Review: Teenage debutant Maja snaps Sunderland´s home drought|
|In-form Neymar is good for all who love football – Emery|
|Napoli´s record goalscorers - how Marek Hamsik compares to Diego Maradona|
|De Bruyne eyes titles over unbeaten season|
|Ninja Turtles invade pitch during PSG clash|
|Muller, Heynckes buoyed by Bayern Munich´s edgy victory|
|I´m confident, but what does that mean? - Wenger gives cryptic answer on Ozil future|
|Real Madrid win five trophies in a calendar year for first time|
|It´s nice to know - Hamsik plays down matching Maradona´s Napoli record|
|Borussia Dortmund 2 Hoffenheim 1: Pulisic late show extends perfect Stoger start|
|Manchester City 4 Tottenham 1: Silva-less City continue to set the gold standard|
|Hughes fumes at Lanzini ´dive´|
|Torino 1 Napoli 3: Historic Hamsik strike sends Sarri´s side top|
|Dyche credits Burnley´s resolve in battling Brighton draw|
|Conte refuses to discuss Chelsea interest in ´really good player´ Van Dijk|
|Real Madrid 1 Gremio 0: Ronaldo free-kick secures Club World Cup glory|
|Silva refuses to question Watford´s attitude amid dismal run|
|Wenger hails Ozil´s decisive ´gem´|
|City´s record run unfairly overshadowing Chelsea form - Conte|
|Murray ´normally very reliable´ from the spot - Hughton|
|Stoke City 0 West Ham 3: Returning Arnautovic has the last laugh|
|Rennes 1 Paris Saint-Germain 4: Two goals, two assists for Neymar|
|Hamsik matches Maradona´s all-time Napoli scoring record|
|Apologetic Spalletti had forgotten losing feeling at Inter|
|We stick to the plan – Valverde not risking Dembele before January|
|Watford 1 Huddersfield Town 4: Deeney sees red as Hornets´ slump continues|
|Chelsea 1 Southampton 0: Alonso extends Blues´ home run|
|Arsenal 1 Newcastle United 0: Ozil stunner sees hosts edge back to winning ways|
|Brighton and Hove Albion 0 Burnley 0: Murray pays the penalty for Seagulls|
|Stuttgart 0 Bayern Munich 1: Ulreich denies former club with last-gasp penalty save|
|Gattuso tries to shrug off Donnarumma, FFP controversies|
|Inter 1 Udinese 3: Leaders leave door open for Napoli as unbeaten run ends|
|Al Jazira 1 Pachuca 4: Jara & Sagal inspire Mexicans to Club World Cup third place|
|Benteke winning over Palace fans after penalty nightmare - Hodgson|
|Allegri defends ´extraordinary´ Dybala after Nedved criticism|
|I didn´t owe Palace team-mates, Benteke claims|
|I´ve never considered leaving PSG, insists Draxler|
|Leicester City 0 Crystal Palace 3: Benteke, Eagles end drought|
|AC Milan´s Fassone requests UEFA help over FFP|
|AC Milan have ´no intention´ of selling Donnarumma|
|A-League Review: Jets keep up pressure, Wanderers get rare win|
|Schalke send Coke on loan to Levante|
|Man Utd´s Matic refuses to concede in Premier League title race|
|Mourinho: I don´t like a circus when you win|
|Keita won´t arrive in January, says Klopp|
|Bring on the noise! Pochettino´s Spurs want to ´kill´ Man City|
|Beat Madrid and PSG can go all the way, Djorkaeff claims|
|Icardi to Real Madrid? Nara will not say yes or no|
|Ronaldo proud to compete with Messi|
|Wenger struggling to solve Arsenal goal drought|
|Pique wants to face Guardiola, City in Champions League final|
|Tevez nearing Boca Juniors return|
|Ronaldo? I was better, says Gremio coach Renato|
|Pique: I understood why Neymar left Barca for PSG|
|Klopp: We´re all fighting for second place|
|Every player has a price – Mourinho hints at January exits|
|Good question! Guardiola ducks Sanchez link and lauds Walker|
|Guardiola addresses Mourinho´s tactical foul claims|
|Call the doctor! Conte protests no malice in David Luiz absence|
|Sheffield Wednesday 0 Wolves 1: Brilliant Neves fires leaders seven clear|
|Premier League title City´s to lose, but Sterling wary of United charge|
|Barcelona´s Deulofeu a Clasico doubt after training injury|
|Salah ´is a player I rate a lot´, says Zidane|
|Allardyce lauds ´invaluable´ Rooney|
|Ramos fit for Club World Cup final|
|Lille sack Bielsa to end failed experiment|
|Manchester United job like Real Madrid, says Mourinho|
|Fernandinho is much better than I was, Guardiola claims|
|That Harry Kane team? – I´m over Guardiola dig, says Pochettino|
|Mourinho open to January moves as Griezmann rumours swirl|
|Berizzo set for Sevilla return after cancer surgery|
|Manchester City will not go unbeaten in Premier League - Guardiola|
|Man City are the best – Pochettino braced for Spurs´ toughest test|
|Conte hopeful over David Luiz´s ´serious´ knee injury|
|Neymar not an injury risk after Brazil trip - Emery|
|Bailly to miss three months due to ankle surgery|
|Klopp defends Liverpool rotation policy|
|Arsenal fan Prince Harry´s wedding day to clash with FA Cup final|
|He´s one of the best – Simeone showers Oblak with praise|
|Juventus won´t sell in-demand Pjaca, agent claims|
|Bolasie in line for Everton return after long-term injury|
|Maradona told Real Madrid to sign Mbappe|
|Sydney FC 3 Melbourne City 1: Champions come from behind to go eight points clear|
|Red-hot Salah wins Player of the Month|
|Heynckes unaware of reported Sanches loan termination|
|Maradona: I´d have won more Ballons d´Or than Ronaldo and Messi|
|Wenger confirms Wilshere contract talks imminent|
|We´ve never been approached by Man United – Wenger rejects Ozil reports|
|Lewandowski demands focus ahead of Christmas|
|Klopp right to rotate at Liverpool – Neville|
|Donnarumma plays down Milan exit rumours|
|Barkley could leave in January – Allardyce|
|Pulisic voted youngest-ever male USA player of the year|
|Griezmann will be allowed to leave – Simeone|
|Guardiola appears to aim another dig at Mourinho|